We previously identified several rare [minor allele frequency (MAF) < 0.01] schizophrenia-associated mutations in PSD-associated protein genes, including DLGAP1, DLGAP2, DLGAP3, and NLGN2 (Sun et al., 2011; Li et al., 2013a, b; Li et al., 2014), which may contribute to some of the pathogenic mechanisms of schizophrenia in certain patients. The gene discussed is NLGN2; the disease is schizophrenia.