Peykov and colleagues identified a rare causative SHANK2 variant (SHANK2A1731S) in schizophrenia (Peykov et al., 2015), and several groups have found missense mutations in SHANK3 in schizophrenia (Gauthier et al., 2010; de Sena Cortabitarte et al., 2017). Here, SHANK2 is linked to schizophrenia.