Reduced ADAMTS13 activity concomitant with increased plasma VWF levels has been observed in thrombotic microangiopathies (TMAs) associated with systemic inflammation, such as in severe sepsis, sepsis-induced disseminated intravascular coagulation (DIC), malignancy, and autoimmune diseases (123). The gene discussed is ADAMTS13; the disease is Genetic thrombotic microangiopathy.