Rather surprisingly, none of the patients affected by COVID-19 carried the HLA-A*02:05, B*58:01, C*07:01, DRB1*03:01 extended haplotype [OR 0.1 (95% CI 0–0.6), P = 0.0006, Pc = 0.015]. The gene discussed is HLA-A; the disease is COVID-19.