IFNG and infection: The effector mechanisms of IFN-γ remains unclear but Verma and Gaffen (121) hypothesized that, as observed in Candida skin infection, IFN-γ may contribute to T. benhamiae destruction and expulsion by activating the fibrinolytic system in the epidermal abscess (122) or promoting M1 macrophages at a later infection stage (Figure 2).