Generally, SPARC is a non-structure matrix-related glycoprotein, contributing to the organization and regulation of extracellular matrix (ECM) networks, including cell shape, cell migration, composition of ECM, and molecular signal transduction (38–40), while SPARC not only serves as a prediction biomarker for various cancers, but also shows a significant effect on the immune cell responses, i.e., its overexpression could inhibit the migration of dendritic cells (DCs) and subsequently obstruct the development of adaptive immunity and promote inflammation (41–43). Here, SPARC is linked to cancer.