IFNA1 and influenza: The efficacy of inclusion of MF59 (an oil-in-water emulsion adjuvant) in trivalent seasonal influenza vaccines was further assessed in immunological naïve infants, which showed a similar transcriptional response in infants as that in adults vaccinated with TIVs, and a positive correlation of early gene signatures of innate immunity at day 1 (including antiviral IFN genes, dendritic cell, etc.)with higher serum antibody titers at day 28 (45, 46).