This notion was further supported by the study of Fujita et al. (41) who identified that one of the transcript variants of NEDD4 gene was highly associated with keloid formation in that it could activate NF-κB signaling pathway in keratinocytes and fibroblasts, confirming the essential role of NF-κB pathway in the development of keloid. This evidence concerns the gene NFKB1 and keloid.