In ABC-DLBCL cells, and in at least one WM-derived cell line, the MYD88L265P mutation promotes the formation of an oncogenic signaling complex comprising Myd88, TLR9 and an IgM-BCR (My-T-BCR super complex) which enforces cooperative survival signaling through the BCR and TLR (16, 17, 76, 78, 79). The gene discussed is TLR9; the disease is diffuse large B-cell lymphoma.