CD8A and neoplasm: MDSCs promote the formation of T regulatory cells (Tregs), the secretion of immunosuppressive IL-10 and TGF-β, and inhibit the activity of cytotoxic CD8 T cells via expression of arginase-1 (Arg1) and inducible nitric oxidase (iNOS) within the TME of several tumor entities including B cell lymphoma (171, 172).