The homeostasis model assessment‐insulin resistance (HOMA ‐ IR) was obtained from the following equation: HOMA ‐ IR = fasting plasma insulin [mIU/L] × fasting plasma glucose [mmol/L]/22.5 (49) or HOMA - IR = fasting glucose level (mg/dL) ×fasting insulin level (μU/mL)/405 (37). This evidence concerns the gene INS and Insulin resistance.