Our group and others have recently reported that ChREBP regulates intestinal fructose absorption by inducing the expression of Glut5, Khk, and Aldob in the intestine and that Chrebp knockout mice consuming a sucrose-based diet show an irritable bowel syndrome-like phenotype, which develops because of fructose malabsorption and an increase in the numbers of acetate-producing bacteria in the intestine (26, 27). Here, MLXIPL is linked to irritable bowel syndrome.