CLCN2 and juvenile absence epilepsy: Certain homozygous or heterozygous CLCN2 mutations can cause two distinct phenotypes: leukoencephalopathy with ataxia (CLCN2; MIM#615651) and idiopathic generalized epilepsy (CLCN2; MIM#607628) including juvenile myoclonic epilepsy and juvenile absence epilepsy.