Thus, lots of pathways related to energy metabolism were enriched in our study, such as “Glycolysis/Gluconeogenesis,” “Insulin signaling pathway,” “Phenylalanine metabolism,” “Type I diabetes mellitus,” and “Tyrosine metabolism.” These findings highlight that the dysfunctional energy metabolism following denervation contribute to muscle atrophy. This evidence concerns the gene INS and type 1 diabetes mellitus.