Recently, CTRP3 has been reported to negatively correlate with lots of cardiometabolic risk factors (Yoo et al., 2013; Choi et al., 2014), such as high blood pressure and obesity (Deng et al., 2015; Wagner et al., 2016). The gene discussed is C1QTNF3; the disease is obesity due to melanocortin 4 receptor deficiency.