Recently, Wei WY and colleagues reported that CTRP3 prevents sepsis-induced cardiomyopathy in mice by activating AMPKα signaling (Wei et al., 2018) and ameliorates doxorubicin-induced cardiomyopathy via activating Sirt1 (Yuan et al., 2018). The gene discussed is SIRT1; the disease is cardiomyopathy.