When we focus on the changes of CTRP3 levels, we found that it was significantly increased in subjects with pre-diabetic subjects (Choi et al., 2012), and decreased significantly in newly diagnosed T2DM (Ban et al., 2014) or T2DM (Deng et al., 2015; Qu et al., 2015; Moradi et al., 2019). Here, C1QTNF3 is linked to type 2 diabetes mellitus.