Excess white adipose tissue associated with increased plasma and adipose tissue pro-inflammatory cytokines such as TNF-α and IL-6 has been reported in both patients with NAFLD and in animal models of NAFLD (Hotamisligil et al., 1993; Hotamisligil et al., 1995; Weisberg et al., 2003). Here, TNF is linked to metabolic dysfunction-associated steatotic liver disease.