Genetic variants in genes such as transmembrane six superfamily member 2 (TM6SF2) (Mahdessian et al., 2014), glucokinase regulatory protein (GCKR) (Petta et al., 2014) and patatin-like phospholipase domain-containing-3 (PNPLA3) are found to associate with NAFLD and NASH, with PNPLA3 classified as one of the most common genetic variations (Eslam et al., 2018). Here, PNPLA3 is linked to metabolic dysfunction-associated steatohepatitis.