In recent years, the ALMN diet-induced NASH model developed by Amylin Pharmaceuticals (hence ALMN model), composed of 40% lipids, 2% cholesterol and water supplemented with fructose, has been reported to display both systemic and liver-specific characteristics of human NASH at 28–30 weeks of AMLN diet feeding (Clapper et al., 2013; Boland et al., 2019). Here, IAPP is linked to metabolic dysfunction-associated steatohepatitis.