A relatively new NASH model has been developed by transiently upregulating ER stress in the liver by delivering major urinary protein urokinase plasminogen activator (MUP-uPA) into the hepatocytes via adeno associated virus coupled with a HFD (Nakagawa et al., 2014; Febbraio et al., 2019). Here, MUPP is linked to metabolic dysfunction-associated steatohepatitis.