In renal cell carcinomas, inhibition of BRD4 by genetic knockdown or JQ1 prevents cell proliferation and EMT, and induces NF-κB-NLRP3-Caspase 1-dependent pyroptosis, providing evidence for BRD4 being a potential target and JQ1 as a therapeutic agent for renal cell carcinomas (Tan et al., 2020). Here, NFKB1 is linked to hereditary clear cell renal cell carcinoma.