CDH1 and cancer: Numerous studies indicated that treatment with decitabine leads to promoter demethylation and reactivates E-cadherin expression in certain cancer cell lines (Graff et al., 1995; Yoshiura et al., 1995; Nakayama et al., 2001; Maruya et al., 2004; Tsutsumida et al., 2004; Ishikawa et al., 2017).