FOXP3 and graft versus host disease: Microbial metabolites like SCFA generated by microbial fermentation of dietary fibers, are able to induce H3 acetylation in the locus of Foxp3; therefore increasing the counts of Tregs directly and TGF-B production in the intestine, the recruitment of Treg, epithelial barrier protection while protecting against danger associated molecular patterns and PAMPs release and decreased apoptosis in gut, all have been shown able to mitigate GVHD.