Interference of acetyl-CoA carboxylase 1 (TACC1) inhibiting the FAS halted clonal expansion of alloreactive T cells in vitro further suggesting the critical role of FAS to promote GVHD development (Byersdorfer et al., 2013; Raha et al., 2016; Cluxton et al., 2019). Here, ACACA is linked to graft versus host disease.