PFKFB3 and graft versus host disease: This is evidenced by inhibition of glycolysis by targeting mTORC1 or 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) that reduced GVHD mortality and morbidity in mouse models (Nguyen et al., 2016; Nguyen et al., 2018).