IGFBP5 and pulmonary fibrosis: Over expression of Insulin like Growth Factor Binding Protein 5 (IGFBP-5) has been correlated with cellular senescence (Kim et al., 2007) and also identified as profibrotic factor which could be an important target for antifibrotic therapies in the case of Idiopathic Pulmonary Fibrosis (Sureshbabu et al., 2011).