The expression levels of β-catenin and Snail in the Rac1 axis were similarly changed, in that they were overexpressed in model mice and decreased in response to BSHX decoction, indicating that podocyte EMT is associated with the activation of Rac1/PAK1/p38MAPK signaling and that BSHX decoction may regulate this process via Rac1 and its downstream signaling, to alleviate renal function deficit and podocyte EMT in DN mice. This evidence concerns the gene PAK1 and liver dysplastic nodule.