ACE and Disorder of lipid metabolism: Strictly controlling blood glucose levels and blood pressure, limiting protein intake, correcting lipid metabolic disorder, quitting smoking, and receiveing treatment with angiotensin-converting enzyme inhibitor, statins, antioxidants, and thiazolidinedione can control DN (Haghighatdoost et al., 2015; Pugliese et al., 2019); however, the incidence and disease progression rates remain relatively high in most patients with DN, and simply controlling blood glucose levels does not offer sufficient protection (Bilous, 2008).