Our data showed that albuminuria and renal function indicators of DN mice were significantly increased compared with the NC group; however, after 8 weeks treatment with metformin or BSHX decoction, there was not only a significant decrease in urinary albumin excretion rate (UAER) in a relatively dose-dependent manner compared to the DN model group, but SCr, BUN, and SUA as well (Figures 1I–L). This evidence concerns the gene ALB and liver dysplastic nodule.