NFKB1 and cardiovascular disorder: These results suggesting that the anti-inflammatory effects of Sal B in cardiovascular system disease may be partly related to its anti-coagulant effects, and inhibiting TNF-α/NF-κB signaling is one of the mechanisms of anti-coagulant effect of Sal B. In addition to regulating Nrf2, ROS can also regulate the activation and translocation of NF-κB into the nucleus to activate the downstream target genes (Ma, 2013).