In addition to the regulation of HSCs and liver sinusoid endothelial cells (LSECs), the improvement of serum ALT and AST of Sal B in a variety of animal models of hepatic fibrosis also shows the improvement of oxidative damage of hepatocytes of Sal B. It has been shown that Sal B have an good antioxidant effect in the hepatic fibrosis models induced by chemical drugs such as TAA, DMN and CCl4 (Table 4). The gene discussed is GPT; the disease is Hepatic fibrosis.