We observed a decrease in MBP immunostaining at 14 months in the hippocampus of APP/PS1 mice, consistent with evidence that myelination is disrupted in this model of AD (Shu et al., 2013; Wu et al., 2017; Chao et al., 2018; Dong et al., 2018). The gene discussed is MBP; the disease is Alzheimer disease.