Recent studies have shown that modulation of agrin signaling by AAV-DOK7 gene therapy (Miyoshi et al., 2017) and MuSK stimulation (Cantor et al., 2018) can increase motor activity and lifespan of the SOD1-G93A ALS mouse model by slowing muscle denervation. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.