Davunetide (NAP, AL-108), an 8-amino acid peptide (Asn-Ala-Pro-Val-Ser-Ile-Pro-Gln) derived from the activity-dependent neuroprotective protein (Gozes et al., 1999), was shown to reduce tau pathology (AT8, AT180, and CP13 site-positive phosphorylated tau) and enhance cognitive function in triple-transgenic AD mice (Matsuoka et al., 2008). Here, MAPT is linked to Alzheimer disease.