MAPT and Alzheimer disease: In fact, TIA-1 co-localizes with pathological tau in human tissue from AD patients (Vanderweyde et al., 2012), and a 50% reduction in TIA-1 expression of cytoplasmic stress granules in P301S tau transgenic (PS-19) mice leads to improvements in behavior and lifespan in parallel with reduced neuronal and synaptic degeneration (Apicco et al., 2018).