For example, in vivo and ex vivo electrophysiological studies have shown dysregulation of synaptic plasticity to be associated with tau deficiency (Ahmed et al., 2014; Kimura et al., 2014b; Regan et al., 2015; Marciniak et al., 2017) and studies in a tau deficiency model showed that nuclear tau is protective against the cellular response to stress (Sultan et al., 2011; Violet et al., 2014). The gene discussed is MAPT; the disease is hyperinsulinemic hypoglycemia, familial, 4.