Indeed, the total protein level and activity of GSK3 in brains with tauopathies seem to correlate with the progression of neurodegeneration (Yamaguchi et al., 1996; Imahori and Uchida, 1997; Pei et al., 1997), and over-activation of GSK3β contributes to tau hyperphosphorylation (Blalock et al., 2004; Guo et al., 2017). This evidence concerns the gene MAPT and tauopathy.