Special attention to these metabolisms in preterm and term infants in neonatal intensive care unit would certainly be worth undertaken, as it is notable that these genes together with Hmgcr have a lifelong pivotal role in brain homeostasis, from the neonatal period to the physiopathology of Alzheimer’s disease in elderly (Leduc et al., 2016). Here, HMGCR is linked to early-onset autosomal dominant Alzheimer disease.