MAPT and frontotemporal dementia: Recently, two novel missense mutations in exon 12, Q336R and Q336H, have been identified in individuals with a familial tauopathy, the Pick’s disease (PiD), characterized by frontotemporal atrophy, neurodegeneration, gliosis, and Tau aggregates (Munoz et al., 2003; Yamakawa et al., 2006; Arendt et al., 2016).