DNMT1 and Alzheimer disease: Examples of such epigenetically targeted drugs include the following: (a) HDAC inhibitors to treat Alzheimer’s disease (AD; NCT03056495 and NCT03533257), Parkinson’s disease (PD; NCT02046434), schizophrenia [NCT00194025, but note that the same drug—Valproate—has been previously tested for the treatment of AD (NCT00071721) with negative results] and cognitive decline (NCT02457507); (b) natural compounds which target DNA methyltransferase (Dnmt) activity to treat AD (NCT01716637 and NCT00951834).