TNF and arthritic joint disease: Peripheral inhibition of TNF-α with infliximab in the context of arthritis, modulates the amyloid pathology by regulating blood-derived and local brain inflammatory cell populations involved in β-amyloid clearance in the brain of double-transgenic 5XFAD/Tg197 AD/TNF mice that develop amyloid deposits and inflammatory arthritis induced by human TNF-α expression (Paouri et al., 2017).