MAPT and Alzheimer disease: The presence in the brain of amyloid beta (Aβ) plaques, composed of Aβ protein and intracellular neurofibrillary tangles, constituted by hyperphosphorylated tau protein, are the two cardinal pathological hallmarks of AD (Querfurth and LaFerla, 2010; Edler et al., 2017; Bulk et al., 2018).