Anti-PD-1/PD-L1 based immunotherapy used as an effective treatment strategy for a wide variety of cancers, including those traditionally considered non-immunogenic (Santarpia et al., 2015), has been recently considered also in animal model of AD as it boosts immune response against the harmful proteins that cause neurodegeneration (Schwartz et al., 2019). Here, CD274 is linked to Alzheimer disease.