In fact, it has been demonstrated that restoring mTOR signaling with rapamycin ameliorates Aβ and tau pathology in several mouse models, preserves blood brain barrier (BBB) integrity, restores cerebral blood flow and brain vascular density and rescues cognitive deficits(Lin et al., 2013; Van Skike et al., 2018; Gureev et al., 2020). Here, MAPT is linked to Cognitive impairment.