APP and Alzheimer disease: Chronic 3,6′-DT administration reduces multiple hallmark features of AD, including glia activation, phosphorylated tau protein, APP, Aβ peptide and Aβ-plaque number along cognitive dysfunction in 3×Tg-AD mice, and leads to synaptic preservation (Gabbita et al., 2012; Tweedie et al., 2012).