MAPT and HIV-associated neurocognitive disorder: Positron emission tomography as molecular imaging provides valuable insight into the pathophysiology underlying HAND, and several studies reported perturbation of metabolism, neuroinflammation, abnormal function of neurotransmitters, and amyloid/tau protein deposition in HAND (Vera et al., 2016; Vera et al., 2017; Sinharay and Hammoud, 2019).