HK1 and hypothyroidism: Some existing data indicate that hypothyroidism induces the detachment of hexokinase 1 (HK1) from the outer mitochondrial membrane by lowering the expression of voltage-dependent anion channel 1 (VDAC1), and this action may be an important cause of the disrupted coordination between glycolysis and oxidative phosphorylation (Regenold et al., 2012).