The previous studies [44, 45] also elucidated that the oxidative stress together with some of its producers, such as reactive oxygen species (ROS), reactive nitrogen species (RNS), oxidases (NOXs), endothelial nitric oxide synthase [46], is associated with the major pathological progressions of the heart failure, ischemia-reperfusion injury and the cardiac hypertrophy. Here, NOS3 is linked to cardiac hypertrophy.