The main analysis of the FIT pilot study by Moss et al.3 assessed the effect of varying faecal haemoglobin concentration (f-Hb) threshold on detection rate of CRC and advanced adenomas (high-risk and intermediate-risk adenomas combined, as defined by Moss et al: see the Pathology section for definitions), and on the colonoscopy rate. The gene discussed is GSTM1; the disease is colorectal carcinoma.