CXCR4 and melanoma: On a molecular level, chemokines and chemokine receptors have been studied as potential trophic factors for metastatic spread of several malignancies, including conjunctival melanoma.48 Immunoreactive scores for chemokine receptors CXCR4 and CCR10 were shown to be related to progression of melanocytic conjunctival lesions towards CM with significant differences in nevi versus melanoma, and CXCR4 upregulation was found to be related to metastatic potential of CM.48