We noticed that miR‐455‐5p and miR‐491‐5p were both reported as cancer‐suppressive miRNAs in ovarian cancer,17, 18 and in this research, by luminescence reporter gene assay, RNA pulldown assay and cell functional assays, we confirmed that LBX2‐AS1 could directly bind to these two miRNAs, by which LBX2‐AS1 increased the malignancy of ovarian cancer cells. This evidence concerns the gene PTGDR and ovarian carcinoma.