We next achieved LBX2‐AS1 knockdown on SKOV3 and OVCAR‐3 cells with or without E2F2 overexpression; we found that the down‐regulation of the overall cell growth of the two ovarian cancer cells by LBX2‐AS1 was significantly weakened by the forced expression of E2F2 or the cotransfection with miR‐455‐5p or miR‐491‐5p inhibitor, as shown in Figure 5B. This evidence concerns the gene E2F2 and ovarian cancer.