RAB7A and Autosomal dominant Charcot-Marie-Tooth disease type 2B: Therefore, endosomes may be facilitating mitochondrial protein synthesis, an important finding which was further substantiated by the discovery that mutations in Rab7a underlying the axonal neuropathy Charcot-Marie-Tooth disease type 2B (CMT2B), disrupt mRNA translation on endosomes, causing a parallel impairment of mitochondrial function [121].