APOE and Mental deterioration: The APOE genotype and PRS-no APOE both hold an association with longitudinal cognitive decline, structural MRI measures (e.g. hippocampal complex cortical thickness), and radioisotope imaging or cerebrospinal fluid identified amyloid and total tau positivity (Harrison et al., 2016, Tan et al., 2017a, Tan et al., 2017b).