MSH6 and Marinesco-Sjogren syndrome: Immunologic-molecular correlations: MSI was associated with CD3 + , CD8 + and FoxP3 + T-cell infiltrate when considering the specific mismatch repair defect (MLH1/PMS2 versus MSH2/MSH6): In MLH1/PMS2 deficient EC significantly higher levels of CD3 + ; CD8 + and FoxP3 + TIL infiltrates were observed compared to MSH2/MSH6-deficient and MSS cases (Fig. 2).