Moreover, ACE2 downregulation by SARS‐CoV‐2 spike protein and related deleterious effects of elevated angiotensin II and decreased angiotensin 1–7 have been proposed as an explanation of the cytokine storm and the multi‐organs dysfunction seen in COVID‐19 patients (Banu et al., 2020; Hoiland et al., 2020). The gene discussed is ACE2; the disease is COVID-19.