Additionally, neuron‐specific enolase (NSE), squamous cell carcinoma antigen (SCC), cancer antigen 125 (CA125), carcinogen‐embryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA21‐1) are commonly used as serologic tumour markers for NSCLC diagnosis and prognosis in clinical settings. This evidence concerns the gene ENO2 and non-small cell lung carcinoma.