Cotreatment of HNSCC cell lines with EMT‐inducing concentrations of EGF and equimolar amounts of EpEX inhibited EGFR‐mediated EMT, along with reduced ERK1/2 phosphorylation and diminished transcription of EMT transcription factors (EMT‐TFs) Snail, Zeb1, and Slug [11]. This evidence concerns the gene MAPK3 and head and neck squamous cell carcinoma.