In order to address potential differences in the evaluation of the expression and the prognostic value of EpCAM and Slug between visual and digital assessment, a tissue microarray (TMA) from the retrospective LMU‐KKG (Ludwig‐Maximilians‐University of Munich, Clinical Cooperation Group “Personalized Radiotherapy in Head and Neck Cancer) cohort of n = 102 HNSCC primary tumors including patients who had undergone surgical resection followed by adjuvant radio(chemo)therapy was generated. Here, EPCAM is linked to head and neck squamous cell carcinoma.