Visual assessment of EpCAM and digital assessment of Slug allowed to stratify HNSCC patients according to the median antigen expression within our cohort with respect to OS (EpCAM‐visual: HR 0.36; 95% CI: 0.18–0.70; P‐value = 0.00174; Slug‐digital: HR 2.34; 95% CI: 1.21–4.51; P‐value = 0.00919; Fig. 4B). This evidence concerns the gene EPCAM and head and neck squamous cell carcinoma.