The G-protein-coupled receptor C5a anaphylatoxin chemotactic receptor 1 (C5aR) belongs to the rhodopsin family of seven transmembrane-containing GPCRs and has been a topic of interest in the last couple of decades due to its relevance in several inflammatory pathologies, such as asthma, arthritis, sepsis, and more recently Alzheimer’s disease and cancer1–3. This evidence concerns the gene C5AR1 and early-onset autosomal dominant Alzheimer disease.