The correlation between ESR2 expression and mean methylation level in exon 0N was weak, positive, non-significant on the convex side of the curvature (Spearman's rank correlation: R = 0.1; P = 0.6; Fig. 3C) and weak, negative, non-significant on the concavity of thoracic scoliosis (Spearman's rank correlation: R = -0.1; P = 0.6; Fig. 3D). Here, ESR2 is linked to Thoracic scoliosis.