Encouragingly, we found that tumor PD-L2 status was inversely correlated with the density of intratumoral CD8+ TILs, suggesting that the level of PD-L2 was not mainly induced by IFN-γ from CD8+ TILs but by other cytokines within the tumor microenvironment. The gene discussed is PDCD1LG2; the disease is neoplasm.