Intriguingly, the expression of tumor PD-L2 was significantly associated with 5-year OS in patients with low CD8+ TILs (CD8+ TILsL/PD-L2H: 54.0% vs CD8+ TILsL/PD-L2L: 35.0%, p < 0.001, Fig. 4C). This evidence concerns the gene PDCD1LG2 and neoplasm.