Low tumor PD-L2 expression was associated with an increased 5-year OS risk among advanced stage colon carcinoma patients by univariate analysis [hazard ratio (HR) = 1.69, 95% CI 1.324–2.161, p < 0.001] and multivariate analysis [HR = 1.594, 95% CI 1.206–2.106, p = 0.001]. This evidence concerns the gene PDCD1LG2 and neoplasm.