We screened glioblastoma cell lines and selected two lines exhibiting high SOX10 expression and promoter hypomethylation, characteristic of RTK I patient samples for use as in vitro models: ZH487, a primary glioblastoma cell line that we established from an RTK I patient sample, and the conventional primary glioblastoma cell line LN229. This evidence concerns the gene SOX10 and glioblastoma.