The 2 variants with this pattern of association include (i) COBLL1:p.N497D which is associated with decreased TG levels and decreased risk of T2D in both HUNT and UK Biobank and of liver disease in HUNT and (ii) LPL:p.S474X which is associated with decreased risk of CAD, T2D, and hypertension. The gene discussed is COBLL1; the disease is type 2 diabetes mellitus.