TMPRSS2 and Familial prostate cancer: For this study, we selected TMPRSS2:ERG fusion as it represents the most common genomic alteration in prostate cancer as well as the next most prevalent genomic alterations in prostate cancer which included deletion of 3p, 5q, 6q, 8p, 10q23, 12p, 13q, 16q, 17p, and 18q.