ESRP1 and metastatic malignant neoplasm in the lymph nodes: Both, high ESRP1 and high ESRP2 staining were significantly associated with adverse tumor features, including advanced tumor stage, high Gleason grade, presence of lymph node metastasis (p < 0.0001 each, Table 2), and high early PSA recurrence (p < 0.0001 each; Fig. 4a-b).