F2 and blood coagulation disease: Our study showed that nearly all children with risk factors for bleeding presented with significant coagulation disorders after CPB, that an early preventive therapy with fibrinogen, prothrombin complex concentrate and platelets improved the hemostasis with no occurrence of thrombosis or need for re-operation and that a low body weight and a low CPB temperature were associated with higher administered fibrinogen doses (mg kg− 1).