NPPB and myocardial ischemia: Cardiovascular (CV) morbidities and mortalities represent the prime complications in patients undergoing chronic hemodialysis (HD).1 In these patients, mortality is generally related to raised pre dialysis drawn cardiac markers such as NT-pro-BNP (Pro-BNP) and troponin T (TnT).2, –4 While Pro-BNP is secreted in response to volume and pressure overload, TnT is released in response to myocardial injury.5 Also pentraxin 3, is considered as a marker of myocardial ischemia,6,7 that is released by cardiac myocytes through the inflammation pathway,8,9 but also by activated leukocytes.10