For example, this list includes RFX-type transcription factor DAF-19, which regulates proteins implicated in intraflagellar transport [11,12], MKS1 (Meckel Syndrome Type 1), BBS3 (Bardet-biedl syndrome 3), and BBS5 (Bardet-biedl syndrome 5) [13,14,15,16]. The gene discussed is BBS5; the disease is Down syndrome.