Lastly, hsa-miR-92a-3p, which was downregulated in femoral artery plaques and upregulated in plasma from PAD patients with CVEs, was found enriched in 57 biological processes including the regulation of apoptosis, negative regulation of transforming growth factor β receptor signaling pathway, negative regulation of endothelial cell migration, positive regulation of nuclear factor-κB (NF-κB)/NF-κB-inducing kinase) signaling, response to ischemia, pre-miRNA processing, negative regulation of autophagy, and negative regulation of endothelial cell proliferation (Figure 7b). This evidence concerns the gene NFKB1 and peripheral arterial disease.