STAT3 and Hepatic fibrosis: However, EVs derived from MSCs were shown to alleviate tetrachloride induced liver fibrosis in a mouse model [145] and, in a similar model, ADSC-derived EVs enriched with miR-181-5p reduced liver fibrosis even more efficiently compared to native ADSC-derived EVs, by inhibiting the STAT3/Bcl-2/Beclin 1 pathway [146].