KDR and Venous thrombosis: Thrombosis occurrence is also inhibited by using GSPE under affecting thrombosis-promoting factors, for instance, P-selectin, von Willebrand factor (vWF), CAMs, demoting factors CD34, vascular endothelial growth factor receptor-2 (VEGFR2), and a disintegrin and metalloproteinase with a thrombospondin type one motif, member 13 (ADAMTS13) [97].